Automated design and scoring engine for IS110-family bridge recombinase variants, nominating 1,029 candidates via an 8-axis PenScore over pre-registered predictions.
Hierarchical certification framework (5-gate TrueWriterScore) for programmable genome editors, with sensitivity analysis, cross-pipeline triangulation, and a RAG Q&A layer over the PEN-STACK.
A verification and grounding layer for AI-driven genome writing. Foundation models and a grounded co-scientist agent propose edits; PEN-STACK checks each against validated tools, never a language model: where a write is safe and durable, which enzyme makes it, and where it goes off-target. Calibrated, provenance-tracked, pre-registered.
