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Python Bindings Packages

Python packages with the GitHub topic python-bindings. Sorted by monthly downloads, with stars and forks.
fastobo
fastobo

Faultless AST for Open Biomedical Ontologies in Python.

206K 34 4
althonos
pyhmmer

Cython bindings and Python interface to HMMER3.

121K 172 20
deliro
moka-py

A high performance caching library for Python written in Rust

112K 313 5
pyimgui
imgui

Cython-based Python bindings for dear imgui

107K 2K 188
althonos
pyfamsa

Cython bindings and Python interface to FAMSA, an algorithm for ultra-scale multiple sequence alignments.

73K 46 6
btclib-org
btclib-secp256k1

Python bindings to libsecp256k1

66K 2 1
jd-boyd
python-lzo

Python bindings for the LZO data compression library

27K 84 46
simonsteiner
openair-rs-py

Fast, typed Python bindings for reading and writing OpenAir airspace files, powered by the Rust openair crate. Includes an OpenAir→JSON CLI

23K 0 0
calvinhxx
fluentqt

FluentQt (Fluent-Qt): Fluent / WinUI-style Qt Widgets UI components and Gallery for native C++ desktop apps, with optional PySide6 bindings and WebAssembly.

23K 161 21
xorbitsai
xllamacpp

xllamacpp - a Python wrapper of llama.cpp

21K 87 16
sbrodehl
pypublicdecompwt

Python bindings for EUMETSAT's PublicDecompWT

18K 3 1
pharmai
plip

Protein-Ligand Interaction Profiler - Analyze and visualize non-covalent protein-ligand interactions in PDB files according to 📝 Schake, Bolz, et al. (2025), https://doi.org/10.1093/nar/gkaf361

15K 722 144
carbonblack
cbapi

Carbon Black API - Python language bindings

14K 145 87
commx
rrdtool

Python bindings for rrdtool

12K 82 28
btclib-org
btclib-libsecp256k1

Python bindings to libsecp256k1

10K 2 1
DanMeon
rhwp-python

PyO3 Python bindings for rhwp — parser and renderer for HWP/HWPX documents (Korean Hancom word processor format)

10K 14 5
althonos
pyopal

Cython bindings and Python interface to Opal, a SIMD-accelerated database search aligner.

9K 11 1
stanislavulrych
tempo-api-python-client

Python bindings for Tempo - https://apidocs.tempo.io/

8K 36 23
bertiniteam
pybertini

Bertini 2: The redevelopment of Bertini in C++ and Python.

8K 114 40
ygxiuming
nano-astar

C++ A* pathfinding on occupancy grids — nanobind, GIL-free, bucket queue for integer costs

6K 0 0
The-Billy-Company
irregex

A full toolkit for building any type of search engine.

6K 1 1
HaarigerHarald
geant4-pybind

Alternative Python bindings for Geant4

6K 45 8
4mritGiri
npdatetime

High-performance Nepali (Bikram Sambat) datetime library based on astronomical calculations. Includes bindings for Python, Django, and JavaScript/WASM.

5K 2 1
bertiniteam
bertini2

Bertini 2: The redevelopment of Bertini in C++ and Python.

5K 114 40
    • Original data from PyPI, GitHub, and OSV; downloads served through ClickHouse
    • Sources & methodology