Computational Neuroscience Python Packages

brian2

Brian is a free, open source simulator for spiking neural networks.

efel

Electrophys Feature Extraction Library

bluepyopt

Blue Brain Python Optimisation Library

bluepyefe

BluePyEfe: Blue Brain Python E-feature extraction

hypercube-hopfield

Modern Hopfield associative memory on a hypercube graph. Sparse local-attention retrieval with exponential capacity. C++23 and Python SDKs.

brian2cuda

A brian2 extension to simulate spiking neural networks on GPUs

ratinabox

A python package for simulating movement and spatial cell types (e.g. place cells, grid cells) in continuous environments.

cleosim

Closed-Loop, Electrophysiology, and Optophysiology experiment simulation testbed for mesoscale neuroscience

neurosush

Brain-inspired AI in PyTorch: simulate spiking neural networks (LIF/AdEx, STDP, dendrites, delays) on GPU and build Thousand Brains / HTM models (spatial pooler, temporal memory, grid cells, active dendrites, predictive coding)

ibl-bwb-eval

Benchmarking large-scale pretraining and across-animal transfer in multi-region Neuropixels recordings from the International Brain Laboratory.

flyconn

Research-grade toolkit over public Drosophila connectomes: harmonized data, signed graphs, uncertainty, validated LIF simulation, declarative experiments

ngclearn

NGC-Learn: Computational Neuroscience and NeuroAI in Python

driada

Dimensionality Reduction for Integrated Activity Data Analysis

neurolib

Easy whole-brain modeling for computational neuroscientists 🧠💻👩🏿‍🔬

neurotune

Package for fitting/optimization of NeuroML models

pointprocess

A C++ Library for Point Process Analysis

biosimulators-pyneuroml

pyNeuroML simulation program via BioSimulators-compliant command-line interface and Docker container

tklfp

Lightweight package for computing the kernel LFP approximation from Teleńczuk et al., 2020

wslfp

Lightweight package for computing the Weighted Sum of synaptic currents LFP proxy from Mazzoni, Lindén et al., 2015

esi-syncopy

Systems Neuroscience Computing in Python: user-friendly analysis of large-scale electrophysiology data

cochlea

Inner ear models for Python

silva-networks

SILVA Networks is a Python package for extended deep equilibrium layers, fixed-point solvers, implicit differentiation, structured operators, diagnostics, and reproducible research notebooks.

spikedist

Spike-train distance metrics (Victor-Purpura, van Rossum) in pure Python with zero dependencies.

foveatorch

👀🔥 Differentiable foveated vision for Deep Learning methods